Manuscript Details - IJARW1316

ManuScript Details
Paper Id: IJARW1316
Title: SIMULTANEOUS DETERMINATION BY RP- HPLC OF PYRIDOXINE HYDROCHLORIDE,DL METHIONINE AND NICOTINAMIDE IN TABLETS
Published in: International Journal Of All Research Writings
Publisher: IJARW
ISSN: 2582-1008
Volume / Issue: Volume 2 Issue 1
Pages: 7
Published On: 7/4/2020 4:02:52 AM      (MM/dd/yyyy)
Main Author Details
Name: Shipra Saini
Institute: MAHATMA GANDHI COLLEGE OF PHARMACEUTICAL SCIENCES, Jaipur, Rajasthan
Co - Author Details
Author Name Author Institute
Dr. Dilip Agarwal MAHATMA GANDHI COLLEGE OF PHARMACEUTICAL SCIENCES, Jaipur, Rajasthan
Dr. Sulekha Mandal MAHATMA GANDHI COLLEGE OF PHARMACEUTICAL SCIENCES, Jaipur, Rajasthan
Abstract
Research Area: Pharmacy, Pharmacology & theraputics
KeyWord: RP-HPLC, Pyridoxine hydrochloride,Dl methionine , Nicotinamide
Abstract: A simple, specific, accurate, precise stability indicating reversed-phase high-performance liquid chromatographic (RP-HPLC) method was developed and validated for the simultaneous determination of Pyridoxine hydrochloride (PYH) Dl methionine (DMN) and Nicotinamide (NCM). An isocratic separation of PYH,DMN and NCM were achieved on C 18, 250 × 4.6 mm ID, 5 μm particle size columns at column oven temperature 37°C with a flow rate of 0.5 mL min−1 and using a diode array detector to monitor the detection at 254 nm. The mobile phase consisted of buffer : acetonitrile : trifluoroacetic acid at a ratio of 30 : 70 : 0.1 (v/v). The retention times of PYH DMN and NCM was found to be 5.25 and 10.14 min, respectively. Suitability, specificity, linearity, accuracy, precision, stability, and sensitivity of this method for the quantitative determination of the drugs were proved by validation in accordance with the requirements laid down by International Conference on Harmonization (ICH) Q2 (R1) guidelines. The proposed method is reliable and robust and can be used as quality control tool for the estimation of these drugs in combined pharmaceutical solid dosage forms.
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IEEE
Shipra Saini , Dr. Dilip Agarwal, Dr. Sulekha Mandal, "SIMULTANEOUS DETERMINATION BY RP- HPLC OF PYRIDOXINE HYDROCHLORIDE,DL METHIONINE AND NICOTINAMIDE IN TABLETS", International Journal Of All Research Writings, vol. 2, no. 1, pp. 15-21, 2020.
MLA Shipra Saini , Dr. Dilip Agarwal, Dr. Sulekha Mandal "SIMULTANEOUS DETERMINATION BY RP- HPLC OF PYRIDOXINE HYDROCHLORIDE,DL METHIONINE AND NICOTINAMIDE IN TABLETS." International Journal Of All Research Writings, vol 2, no. 1, 2020, pp. 15-21.
APA Shipra Saini , Dr. Dilip Agarwal, Dr. Sulekha Mandal (2020). SIMULTANEOUS DETERMINATION BY RP- HPLC OF PYRIDOXINE HYDROCHLORIDE,DL METHIONINE AND NICOTINAMIDE IN TABLETS. International Journal Of All Research Writings, 2(1), 15-21.
SIMULTANEOUS DETERMINATION BY RP- HPLC OF PYRIDOXINE HYDROCHLORIDE,DL METHIONINE AND NICOTINAMIDE IN TABLETS
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SIMULTANEOUS DETERMINATION BY RP- HPLC OF PYRIDOXINE HYDROCHLORIDE,DL METHIONINE AND NICOTINAMIDE IN TABLETS

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