Manuscript Details - IJARW1317

ManuScript Details
Paper Id: IJARW1317
Title: DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF SALBUTAMOL SULPHATE AND AMBROXOL HYDROCHLORIDE IN ORAL LIQUID DOSAGE FORM
Published in: International Journal Of All Research Writings
Publisher: IJARW
ISSN: 2582-1008
Volume / Issue: Volume 2 Issue 1
Pages: 10
Published On: 7/4/2020 4:04:02 AM      (MM/dd/yyyy)
Main Author Details
Name: Mr.Rakesh Kumar
Institute: MAHATMA GANDHI COLLEGE OF PHARMACEUTICAL SCIENCES, Jaipur, Rajasthan
Co - Author Details
Author Name Author Institute
Mukesh Bansal MAHATMA GANDHI COLLEGE OF PHARMACEUTICAL SCIENCES, Jaipur, Rajasthan
Dr. Dilip Agarwal MAHATMA GANDHI COLLEGE OF PHARMACEUTICAL SCIENCES, Jaipur, Rajasthan
Abstract
Research Area: Pharmacy, Pharmacology & theraputics
KeyWord: Salbutamol, Ambroxol, Oral liquid dosage form, RP-HPLC
Abstract: Salbutamol is a bronchodilator and Ambroxol hydrochloride is a mucolytic. Combination of these drugs is used in the formulation of cough syrups. In the literature, there is no method reported for the simultaneous estimation of the drugs in oral liquid dosage form. Hence, the present work is aimed to develop reverse phase HPLC method for the simultaneous determination of Salbutamol sulfate (SAL), and Ambroxol hydrochloride (AMB) in oral liquid dosage form and validation of the developed method. The chromatographic separation of the drugs was achieved with the mobile phase system sodium dihydrogen phosphate buffer pH 3.0: acetonitrile: methanol in the ratio of 65:10:25 with the flow rate of 1 mL/min and injection volume 10 µL. An Inertsil C8-3 (250 × 4.6 mm, 5 µm) column was used, and the detection wavelength was 276 nm. This system produced sharp peaks with good resolution, minimum tailing and satisfactory retention times of SAL and AMB were found to be 3.157and 11.883 min respectively indicating the suitability of the system. The developed method was validated for various parameters accuracy, precision, linearity, robustness, and specificity as per ICH guidelines.
Citations
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IEEE
Mr.Rakesh Kumar, Mukesh Bansal , Dr. Dilip Agarwal, "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF SALBUTAMOL SULPHATE AND AMBROXOL HYDROCHLORIDE IN ORAL LIQUID DOSAGE FORM", International Journal Of All Research Writings, vol. 2, no. 1, pp. 22-31, 2020.
MLA Mr.Rakesh Kumar, Mukesh Bansal , Dr. Dilip Agarwal "DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF SALBUTAMOL SULPHATE AND AMBROXOL HYDROCHLORIDE IN ORAL LIQUID DOSAGE FORM." International Journal Of All Research Writings, vol 2, no. 1, 2020, pp. 22-31.
APA Mr.Rakesh Kumar, Mukesh Bansal , Dr. Dilip Agarwal (2020). DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF SALBUTAMOL SULPHATE AND AMBROXOL HYDROCHLORIDE IN ORAL LIQUID DOSAGE FORM. International Journal Of All Research Writings, 2(1), 22-31.
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF SALBUTAMOL SULPHATE AND AMBROXOL HYDROCHLORIDE IN ORAL LIQUID DOSAGE FORM
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DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF SALBUTAMOL SULPHATE AND AMBROXOL HYDROCHLORIDE IN ORAL LIQUID DOSAGE FORM

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