ManuScript Details
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Paper Id:
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IJARW1065
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Title:
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DEVELOPMENT AND EVALUATE RELEASE RATE SUSTAINING PROPERTIES OF GUAR GUM, XANTHAN GUM AND HPMC, ALONE AND IN DOUBLE AND IN TRIPLE MIXER, IN A MATRIX TABLET FORMULATION
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| Published in: |
International Journal Of All Research Writings |
| Publisher: |
IJARW |
| ISSN: |
2582-1008 |
| Volume / Issue: |
Volume 1 Issue 4 |
| Pages: |
7
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| Published On: |
11/2/2019 12:19:09 AM (MM/dd/yyyy) |
Main Author Details
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Name:
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ISHRAT ZAHOOR |
| Institute: |
MAIP, jaipur |
Co - Author Details
| Author Name |
Author Institute |
| irfan ahmad malik |
Maip, jaipur |
| Dr. Anil Goyal |
Maip, jaipur |
| Dr. Rajesh Kumar Asija |
MAIP, jaipur |
Abstract
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Research Area:
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Pharmacy, Pharmacology & theraputics |
| KeyWord: |
Propranolol hydrochloride, Guar gum, Tablet, Formulation, In-vivo, In-vitro |
| Abstract: |
This study was conducted to develop and evaluate sustained release matrix tablet using propranolol hydrochloride as a model drug and sustained release pellets using hydralazine hydrochloride as model drug.
Matrix tablets prepared incorporating either single or a combination of release rate retarding materials were shown to possess good pharmacotechnical properties. The drug release profiles of various formulations showed that these were successful in effectively sustaining the drug release from the matrix tablets, as set in objectives. There are various formulations in this study which can be used to prepare commercially available oral sustained release dosage forms with desirable pharmaceutical properties and drug release profile. If a 12h release profile is desired any formulation containing the HPMC alone or in combination as rate retardant can be used. If seeking a 24h release profile the formulations containing xanthan gum alone or in combinations can be used to design such dosage form. The selected formulations were evaluated in-vivo using rabbits as model animals and Inderal LA® 80mg as the reference drug product. The results of in-vivo studies showed that the pharmacokinetic parameters were comparable for test and reference formulations. It was concluded that the suggested formulations can be used to prepare the sustained release dosage form with desirable pharmacotechnical properties including the release profile. The results of invitro and invivo evaluation correlate well with the objectives of the study.
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Citations
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IEEE
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ISHRAT ZAHOOR, irfan ahmad malik, Dr. Anil Goyal, Dr. Rajesh Kumar Asija, "DEVELOPMENT AND EVALUATE RELEASE RATE SUSTAINING PROPERTIES OF GUAR GUM, XANTHAN GUM AND HPMC, ALONE AND IN DOUBLE AND IN TRIPLE MIXER, IN A MATRIX TABLET FORMULATION", International Journal Of All Research Writings,
vol. 1, no. 4, pp. 51-57, 2019.
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MLA
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ISHRAT ZAHOOR, irfan ahmad malik, Dr. Anil Goyal, Dr. Rajesh Kumar Asija "DEVELOPMENT AND EVALUATE RELEASE RATE SUSTAINING PROPERTIES OF GUAR GUM, XANTHAN GUM AND HPMC, ALONE AND IN DOUBLE AND IN TRIPLE MIXER, IN A MATRIX TABLET FORMULATION." International Journal Of All Research Writings,
vol 1, no. 4, 2019, pp. 51-57.
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APA
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ISHRAT ZAHOOR, irfan ahmad malik, Dr. Anil Goyal, Dr. Rajesh Kumar Asija (2019). DEVELOPMENT AND EVALUATE RELEASE RATE SUSTAINING PROPERTIES OF GUAR GUM, XANTHAN GUM AND HPMC, ALONE AND IN DOUBLE AND IN TRIPLE MIXER, IN A MATRIX TABLET FORMULATION. International Journal Of All Research Writings,
1(4), 51-57.
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DEVELOPMENT AND EVALUATE RELEASE RATE SUSTAINING PROPERTIES OF GUAR GUM, XANTHAN GUM AND HPMC, ALONE AND IN DOUBLE AND IN TRIPLE MIXER, IN A MATRIX TABLET FORMULATION
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DEVELOPMENT AND EVALUATE RELEASE RATE SUSTAINING PROPERTIES OF GUAR GUM, XANTHAN GUM AND HPMC, ALONE AND IN DOUBLE AND IN TRIPLE MIXER, IN A MATRIX TABLET FORMULATION
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