| KeyWord: |
Metoprolol Succinate, Amlodipine Besylate, Tablets, HPMC, Bilayered Tablet
Metoprolol Succinate, Amlodipine Besylate, Tablets, HPMC, Bilayered Tablet
Metoprolol Succinate, Amlodipine Besylate, Tablets, HPMC, Bilayered Tablet
Metoprolol Succinate, Amlodipine Besylate, Tablets, HPMC, Bilayered Tablet
Metoprolol Succinate, Amlodipine Besylate, Tablets, HPMC, Bilayered Tablet
Metoprolol Succinate, Amlodipine Besylate, Tablets, HPMC, Bilayered Tablet
Metoprolol Succinate, Amlodipine Besylate, Tablets, HPMC, Bilayered Tablet
Metoprolol Succinate, Amlodipine Besylate, Tablets, HPMC, Bilayered Tablet
Metoprolol succinate, Amlodipine Besylate, Tablets, HPMC, Bilayered tablet |
| Abstract: |
In the present study an attempt was made to prepare Bilayer tablets of Amlodipine besylate (IR) and Metoprolol succinate(ER) by direct compression technique with excipients like MCC 102, SSG, aerosil & magnesium stearate for Amlodipine release layer and starch 1500, HPMC K15M, HPMC K4M, aerosil & sodium stearyl fumarate for Metoprolol release layer. Prepared bilayered tablets were evaluated for hardness, friability, weight variation, drug content uniformity, drug-polymer interaction, in vitro drug release and short-term stability studies. Among the various formulations prepared, formulation A3 with SSG (5%), formulation M8 (with 55% of HPMC K15M and 10% of HPMC K4M) showed comparatively good release which complies the dissolution requirements as per USP. |
